Healing Within Reach: Join for only $297. TAP TO READ

An Overview of Limbic System Disorders

Written by Shannon

Published on Dec 07, 2023

Updated on Feb 10, 2026

Updated on Feb 10, 2026

Table of Contents
An Overview of Limbic System Disorders
The limbic system is a central part of the brain that regulates emotions, memory, motivation, and many autonomic functions. When this system becomes dysregulated, it can result in an overactive limbic system or various limbic system diseases, impacting mental, emotional, and physical well-being. This article explores practical strategies to support the limbic system and manage disorders of limbic system function using neuroplasticity-based exercises.

At re-origin, we’ve helped thousands of people overcome symptoms of chronic health conditions by learning to calm the limbic system. Learn more about the re-origin program here.

What are the Major Functions of the Limbic System?

The limbic system is responsible for processing emotions, forming memories, and maintaining physiological balance. When it becomes overworked, the body may remain in a heightened state of alert, which can contribute to fatigue, difficulty focusing, and emotional instability. These patterns are often the root cause of diseases of the limbic system and related functional disturbances.[1].

What Happens When the Limbic System Malfunctions?

Individuals with an overactive limbic system may experience chronic stress, mood swings, irritability, or difficulty regulating emotions. While these signs do not always indicate a specific condition, they can point to underlying limbic system impairment. Neuroplasticity allows the brain to create new neural pathways, helping to restore balance and calm.

An Overview of Limbic System Disorders

Common Disorders Resulting from Limbic System Impairment

Several of the most common health conditions that people experience can be tied back to an overworked limbic system. When it isn’t operating how it’s meant to, it can create a domino effect throughout the body, affecting entire bodily systems such as the immune and digestive systems.

Anxiety and Depression

With an estimated 18% of the American population suffering from anxiety and another 9.5% that experience depression, anxiety and depression are two of the most predominant mental health disorders in the world[2]. These mental illnesses do not only affect the mind, as most people that live with them experience physical symptoms as well such as appetite issues, insomnia, headaches, and fatigue. When the limbic system is overactivated and trapped in a consistent stress response cycle, the result is often anxiety and depression. Studies suggest that the heightened levels of cortisol in the body from the malfunctioning limbic system play a large role in cases of anxiety and depression[3].

Chronic Fatigue Syndrome

When the nervous system becomes conditioned to overactive the sympathetic branch, the body’s resources may be allocated away from long term functions such as detoxification, tissue repair, digestion, and immune and endocrine system functions – in favor of should term inflammatory activity. Over time, this can place excess stress on the body, leaving the person feeling drained of energy. Furthermore, the part of the brain that regulates emotions can become depleted of natural “feel-good” chemicals such as dopamine, serotonin, oxytocin, and endorphins, leading the person to feel flat or depressed. Fortunately, their is neuroscience data and tons of anecdotal evidence to suggest that the dysfunction can be reversed, and those suffering from CFS and anxiety disorders can recover the function of the autonomic nervous system which results in homeostasis.

Addiction

In many cases, addiction can be tied back to a malfunctioning limbic system. The feelings of motivation, pleasure, and reward are connected to the limbic system, which is why addiction can be related to an impairment here[6]. When certain drugs are regularly used, there is a rush of the neurotransmitter dopamine, which provides us with the sensation of reward. The brain becomes dependent on addictive substances and starts associating them with survival, however there is a solution to this negative relationship with addictive substances, brain rewiring. It’s suggested that through introducing cognitive modifications, it’s possible to overcome addiction. The neurons in the brain can be restructured to stop depending on addictive substances when the appropriate training methods are applied, putting an end to the destructive limbic loop.

Dementia

Dementia is a condition that is characterized by memory loss, confusion, disorientation, and mood swings. Neural connections within the brain, namely the limbic system, can begin to deteriorate as a result of trauma, depression, and genetic predispositions[4]. It’s understood that there are no known cures for dementia and that essential neurotransmitters that play a major role in memory retention (i.e., acetylcholine) are diminished in those that are suffering from this degenerative illness. While this may be the case, scientific evidence does suggest that early intervention and the application of neuroplasticity training can help delay the progression of cognitive decline[2].

How to Calm & Rewire The Limbic System

Regular practice of neuroplasticity exercises can calm an overactive limbic system, prune harmful neural connections, and strengthen new beneficial pathways. Evidence supports the use of brain training to manage limbic system diseases and other disorders of limbic system function. By retraining the brain to recognize safety, the body can return to homeostasis, allowing both mental and physical calm to emerge naturally.

Even when facing limbic system impairment, consistent practice with structured programs like those offered by re-origin can help restore balance and break the cycles of chronic stress.

NEW TO NEUROPLASTICITY?

Sign Up For
7 Days of Brain Retraining

Claim Your FREE Mini-Program 💌

There is Hope for Healing Your Limbic System

re-origin is a community that is dedicated to helping anyone that struggles with a wide range of chronic health issues through science-backed neuroplasticity training. We’re here to offer support, guidance, and answers that you have likely not found anywhere else. It’s completely possible to rewire the brain from making you feel constantly stressed, worried, and overall unwell to balanced, healthy, and in control again. You’re capable of so much more than you may realize, and we’re here to assist you with harnessing these capabilities each and every step of the way. Learn more about the re-origin program here.

An Overview of Limbic System Disorders

References
  1. Johns Hopkins Medicine. (n.d.). Mental health disorder statistics. Johns Hopkins Medicine. Retrieved October 18, 2024, from https://www.hopkinsmedicine.org/health/wellness-and-prevention/mental-health-disorder-statistics
  2. Colman, A. M., & Bullmore, E. T. (2010). Neurobiological correlates of depression: Challenges and future directions. Philosophical Transactions of the Royal Society B: Biological Sciences, 365(1537), 2595–2605. https://doi.org/10.1098/rstb.2010.0279
  3. Harvard Health Publishing. (2019, March 29). What causes depression? Harvard Health Publishing. https://www.health.harvard.edu/mind-and-mood/what-causes-depression
  4. Lecturio. (2020, April 7). Limbic system disorders: Symptoms and causes. Lecturio Medical Education. https://www.lecturio.com/magazine/limbic-system-disorders/
  5. Holmes, E. A., Craske, M. G., & Graybiel, A. M. (2014). A call to action: Translational science needs to be taken to the next level. Nature Neuroscience, 17(2), 153–160. https://doi.org/10.1038/nn.3623
  6. Stewart, R. S., & Friston, K. J. (1998). Neuroimaging in psychiatry: Functional insights into brain pathology. British Journal of Psychiatry, 173, 268–275. https://pubmed.ncbi.nlm.nih.gov/9783839/
Share This Blog Post
Share This Blog Post

Join the Journey
Get the latest tools & insights on brain retraining and healing chronic illness!

Ready to Rewire?

Subscribe & get 10% off your first year at re-origin.

Read More Blog Posts

Reaffirming Our Mission: Healing Within Reach

re-origin is built on a simple belief: everyone deserves access to the tools and knowledge to retrain their brain and reclaim their health. As the world faces growing uncertainty and financial strain, we’re reminded why that mission matters more than ever.

That’s why, right now, the re-origin program is $297 ($82 off) as a reflection of our ongoing commitment to accessibility for all. Because healing IS within reach.

— In healing, your friends at re-origin.

Get started with code HEAL👇